Chloroethylnitrosoureas
WebCategory filter: Show All (16)Most Common (0)Technology (0)Government & Military (4)Science & Medicine (1)Business (2)Organizations (12)Slang / Jargon (0) Acronym … WebChloroethylnitrosoureas (CENUs) are bifunctional antitumor alkylating agents, which exert their antitumor activity through inducing the formation of dG-dC interstrand crosslinks (ICLs) within DNA double strand. However, the complex process of tumor biology enables tumor cells to escape the killing t …
Chloroethylnitrosoureas
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WebApr 1, 2024 · Chloroethylnitrosoureas (CENUs) are bifunctional antitumor alkylating agents, which exert their antitumor activity through inducing the formation of dG-dC … WebChloroethylnitrosourea. Chloroethylnitrosourea cross-links are prevented from forming by the removal of the chloroethyl lesion from the O6 position before rearrangement or by …
WebSep 15, 1987 · Both in vitro and in vivo metazolastone caused formation of DNA alkali-labile sites (assessed by alkaline elution techniques) which were present in similar … WebSep 1, 1987 · Abstract. DNA damage caused by methazolastone [an analogue of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide which does not require metabolic activation] was investigated in L-1210 leukemia which is sensitive to this drug and in a L-1210 subline [L-1210/N,N-bis(2-chloroethyl)-N-nitrosourea (BCNU)] which is resistant to both …
WebChloroethylnitrosoureas (BCNU, CCNU, meCCNU, fotemustine, ACNU, clomesone) and related methylating agents (methyltriazenes: DTIC, temozolomide; methylnitrosoureas: … WebMar 23, 2015 · Chloroethylnitrosoureas (CENUs), which are bifunctional alkylating agents widely used in the clinical treatment of cancer, exert anticancer activity by inducing crosslink within a guanine-cytosine DNA base pair. However, the formation of dG-dC crosslinks can be prevented by O6-alkylguanine-DNA alkyltransferase (AGT), ultimately leading to drug …
Web2. Guohui Sun, Lijiao Zhao,* Tengjiao Fan, Sisi Li, Rugang Zhong. Investigations on the effect of O6-benzylguanine on the formation of dG-dC interstrand crosslinks induced by chloroethylnitrosoureas in human glioma cells using a stable isotope dilution high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. …
WebTemozolomide is more cytotoxic against L1210 than against a subline L1210/BCNU, resistant to chloroethylnitrosoureas. Using [methyl-3H] temozolomide we found that after 1 h exposure the amount of O6-methylguanine (O6mGua) was twice as high in L1210 than in L1210/BCNU whereas the amount of N7 mGua was approximately the same in the … how to sell adopts on toyhouseWebThis paper provides an overview of cancer chemotherapy with special reference to the pharmacokinetics of the nitrosoureas. At physiological PH, the chloroethylnitrosoureas can be decomposed into an isocyanate and 2-chloroethyl diazene hydroxide. Therefore, it is clear that they have both alkylation … how to sell a vehicle in oregonWebThis study compares the level of DNA-DNA interstrand crosslinking in murine bone marrow with the decrease in mean number of blood progenitor cells in mice treatedwith chloroethylnitrosoureas. how to sell after effects templatesWebNov 18, 2024 · Investigated the mechanisms by which polyamine depletion sensitizes human growth cells to chloroethylnitrosoureas. Preformed computational molecular simulation for DNA press RNA. Label Researcher 2024 - 2024. how to sell aftershock ticketsWebMolecular docking of potential cytotoxic alkylating carmustine derivatives 2-chloroethylnitrososulfamides analogues of 2-chloroethylnitrosoureas J Biomol Struct Dyn. 2024 Aug;39 (12):4256-4269. doi: 10.1080/07391102.2024.1776638. Epub 2024 Jun 16. Authors Wafa Soudani 1 , Fatima Zohra Hadjadj-Aoul 2 , Mohammed Bouachrine 3 4 … how to sell adtWebWe investigated the relative contribution of the two Escherichia coli DNA alkyltransferases (ATases) to the increased sensitivity of ATase-deficient bacteria to the mutagenic and lethal effects of chloroethylnitrosoureas (CNU). The ogtencoded protein was the principal determinant in resistance to th … how to sell ads on googleWeb@article{osti_6799524, title = {Sensitivity of human cell strains having different abilities to repair O6-methylguanine in DNA to inactivation by alkylating agents including chloroethylnitrosoureas}, author = {Scudiero, D A and Meyer, S A and Clatterbuck, B E and Mattern, M R and Ziolkowski, C H and Day, R S}, abstractNote = {In order to … how to sell advertising