WebSep 14, 2016 · Abstract. RNA-binding proteins play critical roles in the regulation of gene expression. Among several families of RNA-binding proteins, PUF (Pumilio and FBF) proteins have been the subject of ... WebMar 16, 2004 · Messenger RNAs that are associated with each of the five Puf RNA-binding proteins can be grouped according to function and localization, suggesting that tagging of transcripts by specific RNA-binding proteins coordinates the control of their localization, translation, and decay.
Extensive Association of Functionally and Cytotopically Related
WebMay 28, 2024 · The PUF family of RNA-binding proteins is highly conserved in eukaryotes, and its members regulate gene expression, mitochondrial biogenesis, and RNA … WebGong F, Dong D, Zhang T, Xu W. Long non-coding RNA FENDRR attenuates the stemness of non-small cell lung cancer cells via decreasing multidrug resistance gene 1 (MDR1) expression through competitively binding with RNA binding protein HuR. Eur J Pharmacol. 2024;853:345–352. 14. cpm escalation
Engineering RNA-binding proteins for biology - FEBS Press
WebFeb 1, 2011 · The PUF family of RNA-binding proteins are posttranscriptional regulators present throughout the eukaryotic domain. PUFs bind to specific recognition sequences in the 3′ untranslated regions (3′ UTRs) of mRNAs to control the stability and translation of transcripts 1, 2.All PUFs contain a PUM-HD-type RNA-binding domain 3, 4, reviewed in 1, … WebJun 1, 2009 · Here we focus on the RNA-binding specificity of a C. elegans PUF protein, PUF-11. Our findings reveal that PUF-11 binds RNA in multiple modes, in which the protein can accommodate variable spacings between two distinct recognition elements. We propose a structural model in which flexibility in the central region of the protein enables … WebJan 30, 2024 · The PUF protein family (Pumilio and FBF) is composed of RNA-binding proteins highly conserved among most eukaryotic organisms. Previous investigations … cpme services