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Puf rna binding protein

WebSep 14, 2016 · Abstract. RNA-binding proteins play critical roles in the regulation of gene expression. Among several families of RNA-binding proteins, PUF (Pumilio and FBF) proteins have been the subject of ... WebMar 16, 2004 · Messenger RNAs that are associated with each of the five Puf RNA-binding proteins can be grouped according to function and localization, suggesting that tagging of transcripts by specific RNA-binding proteins coordinates the control of their localization, translation, and decay.

Extensive Association of Functionally and Cytotopically Related

WebMay 28, 2024 · The PUF family of RNA-binding proteins is highly conserved in eukaryotes, and its members regulate gene expression, mitochondrial biogenesis, and RNA … WebGong F, Dong D, Zhang T, Xu W. Long non-coding RNA FENDRR attenuates the stemness of non-small cell lung cancer cells via decreasing multidrug resistance gene 1 (MDR1) expression through competitively binding with RNA binding protein HuR. Eur J Pharmacol. 2024;853:345–352. 14. cpm escalation https://waatick.com

Engineering RNA-binding proteins for biology - FEBS Press

WebFeb 1, 2011 · The PUF family of RNA-binding proteins are posttranscriptional regulators present throughout the eukaryotic domain. PUFs bind to specific recognition sequences in the 3′ untranslated regions (3′ UTRs) of mRNAs to control the stability and translation of transcripts 1, 2.All PUFs contain a PUM-HD-type RNA-binding domain 3, 4, reviewed in 1, … WebJun 1, 2009 · Here we focus on the RNA-binding specificity of a C. elegans PUF protein, PUF-11. Our findings reveal that PUF-11 binds RNA in multiple modes, in which the protein can accommodate variable spacings between two distinct recognition elements. We propose a structural model in which flexibility in the central region of the protein enables … WebJan 30, 2024 · The PUF protein family (Pumilio and FBF) is composed of RNA-binding proteins highly conserved among most eukaryotic organisms. Previous investigations … cpme services

Programmable RNA methylation and demethylation using PUF …

Category:NcPuf1 Is a Key Virulence Factor in Neospora caninum

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Puf rna binding protein

Engineering a conserved RNA regulatory protein repurposes its ... - eLife

WebBackground: Neospora caninum is an apicomplexan parasite that infects many mammals and particularly causes abortion in cattle. The key factors in its wide distribution are its virulence and ability to transform between tachyzoite and bradyzoite forms. However, the factors are not well understood. Although Puf protein (named after Pumilio from … WebDec 14, 2015 · S. cerevisiae Puf1p (Jsn1p) and the closely related protein, Puf2p are termed “noncanonical,” in that they differ from most PUF proteins in RNA-binding specificity, sequence motifs, and numbers of repeats. …

Puf rna binding protein

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WebBackground: Neospora caninum is an apicomplexan parasite that infects many mammals and particularly causes abortion in cattle. The key factors in its wide distribution are its … WebSep 14, 2015 · Proteins bind and control mRNAs, directing their localization, translation and stability. Members of the PUF family of RNA-binding proteins control multiple mRNAs in a …

WebJul 11, 2024 · Abstract. PUF proteins, named for Drosophila Pumilio (PUM) and Caenorhabditis elegans fem-3-binding factor (FBF), recognize specific sequences in the mRNAs they bind and control.RNA binding by classical PUF proteins is mediated by a characteristic PUM homology domain (PUM-HD). The Puf1 and Puf2 proteins possess a … WebThe eukaryotic Puf proteins bind 3′ untranslated region (UTR) sequence elements to regulate the stability and translation of their target transcripts, and such regulatory events …

WebDec 11, 2015 · PUF proteins are a conserved group of sequence specific RNA-binding proteins that bind to RNA in a modular fashion. The RNA-binding domain of PUF proteins … WebThe Pumilio (Pum)/Puf family proteins are ubiquitously present across eukaryotes, including yeast, plants and humans. They generally bind to the 3' untranslated regions of single …

WebJan 30, 2024 · Post-transcriptional regulation of gene expression plays a crucial role in many processes. In cells, it is mediated by diverse RNA-binding proteins. These proteins can influence mRNA stability, translation, and localization. The PUF protein family (Pumilio and FBF) is composed of RNA-binding proteins highly conserved among most eukaryotic …

WebJournal of Molecular Biology Feb 2013. Authors: Wu, .J, Campbell, Z.T., Menichelli, E., Wickens, M., Williamson, J.R. Abstract: The Pumilio and … cpme nationaleWebMar 16, 2004 · Messenger RNAs that are associated with each of the five Puf RNA-binding proteins can be grouped according to function and localization, suggesting that tagging … cpme significationWebPUF proteins are a conserved group of sequence specific RNA-binding proteins that bind to RNA in a modular fashion. The RNA-binding domain of PUF proteins typically consists of … magneticasoftWebMay 21, 2006 · PUF proteins, a family of RNA-binding proteins, interact with the 3′ untranslated regions (UTRs) of specific mRNAs to control their translation and stability. … cpme tarnWebAug 1, 2024 · The RNA-binding domain of classical PUF proteins (e.g., Drosophila Pumilio and human PUM1) consists of eight imperfect, helical tandem repeats (PUF repeats) that … cp metric crosscpmevansvillecomWebtechnologies and modular RNA-binding proteins have been developed10-12. Here, we harnessed the mRNA-sequence specificity of the modular RNA-binding proteins Pumilio and FBF homology protein (PUF). The mRNA binding region of PUFs consists of eight structural repeats, each containing ~36 amino magnetic autocontrol mib 30 manual